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KMID : 1134820100390030363
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Journal of the Korean Society of Food Science and Nutrition
2010 Volume.39 No. 3 p.363 ~ p.368
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Effects of Artemisia Prineps Extract on Bone Metabolism
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Lee Seung-Min
Kim Myung-Gyou
Lee Seung-Youn
Kang Tae-Hoon
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Abstract
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Artemisia princeps has been utilized as a traditional medicine for a variety of diseases in Korea. In this study, we investigated the effects of Artemisia princeps extract (APE) on bone metabolism both in vitro using primary mouse bone marrow-derived macrophage and in vivo using ovariectomized rats. APE decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells and TRAP activity. Also, APE inhibited bone resorptive activity of differentiated osteoclasts. In ovariectomized rats, APE alleviated the decrease in the trabecular bone mineral density. These results showed that APE might be useful for the prevention of postmenopausal bone loss.
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KEYWORD
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Artemisia princeps, osteoclast, tartrate-resistant acid phosphatase activity, bone resorptive activity, bonemineral density
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